Cranberries vs. Antibiotics: Impact on UTI Recurrence in Women.

Abstract

This systematic review explores the effectiveness of cranberry products, including juice and supplements, in preventing recurrent urinary tract infections (UTIs) in women. Fourteen studies, predominantly randomized controlled trials, were included in the analysis. The results were mixed, but cranberry supplements, particularly those standardized for proanthocyanidins (PACs), demonstrated potential in reducing UTI recurrence in certain populations. Variability in efficacy was observed, influenced by factors such as product formulation, PAC concentration, dosage, and study population. Cranberry juice showed inconsistent benefits, likely due to differences in active compound content and challenges in maintaining regular consumption. Supplements, especially those with higher PAC concentrations, appeared more effective, providing a convenient non-antibiotic alternative for UTI prevention. This may be particularly relevant in reducing antibiotic resistance associated with frequent UTI treatment. The findings suggest that cranberry products could be a viable preventive option, especially for women at lower risk for UTIs. However, further research is needed to establish optimal dosages and to identify populations most likely to benefit. These findings emphasize the importance of patient-centered approaches, considering individual preferences, tolerability, and lifestyle factors when recommending cranberry products. Overall, cranberry supplements hold promise as a complementary strategy for reducing UTI recurrence in women while mitigating reliance on antibiotics.